1-(5-Bromo-1H-Indazol-3-yl) ethan-1-one

1-(5-Bromo-1H-Indazol-3-yl) ethan-1-one - Names and Identifiers

Name	1-(5-bromo-1H-indazol-3-yl)ethanone
Synonyms	3-Acetyl-5-Bromoindazole 3-Acetyl-5-bromo-1H-indazole 1-(5-bromo-1H-indazol-3-yl)ethanone 1-(5-BroMo-1H-indazol-3-yl)-ethanone Ethanone,1-(5-broMo-1H-indazol-3-yl)- Ethanone, 1-(5-bromo-1H-indazol-3-yl)- 1-(5-Bromo-1H-Indazol-3-yl) ethan-1-one
CAS	886363-74-2
InChI	InChI=1S/C9H7BrN2O/c1-5(13)9-7-4-6(10)2-3-8(7)11-12-9/h2-4H,1H3,(H,11,12)

1-(5-Bromo-1H-Indazol-3-yl) ethan-1-one - Physico-chemical Properties

Molecular Formula	C9H7BrN2O
Molar Mass	239.07
Density	1.674±0.06 g/cm3(Predicted)
Boling Point	403.8±25.0 °C(Predicted)
pKa	10.62±0.40(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C

1-(5-Bromo-1H-Indazol-3-yl) ethan-1-one - Introduction

1-(5-bromo-1H-indazol-3-yl)ethanone is an organic compound with the chemical formula C10H8BrN3O. It has the form of a white solid.

Its main use has two aspects:
1. as an intermediate in organic synthesis, it can be used to prepare other indazole compounds.
2. As a pharmaceutical raw material, it can be used to synthesize biologically active indazole drugs.

The method for preparing 1-(5-bromo-1H-indazol-3-yl)ethanone can generally be carried out by the following steps:
1. Indazole is reacted with 1,5-dibromopentane at ambient temperature to form 6-bromoindazole.
2. 6-bromoindazole is reacted with a basic substance to obtain 5-bromoindazole.
3.5-bromoindazole reacts with acetyl bromide to generate 1-(5-bromo-1H-indazol-3-yl)ethanone under alkaline conditions.

Regarding safety information, 1-(5-bromo-1H-indazol-3-yl)ethanone is an organic compound, and its toxicity and irritation should be noted. Appropriate protective measures, including gloves, goggles and protective clothing, need to be taken during use and handling, and operation in a well-ventilated environment. Avoid inhalation, contact with skin and eyes. If exposed or inhaled, rinse immediately with plenty of water and seek medical attention immediately. In addition, it should be stored in a dry and ventilated place, away from fire and oxidizing agents.

Last Update：2024-04-09 20:52:54